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  • 產(chǎn)品名稱：CASP5 抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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詳情介紹：

中文名稱： CASP5 抗原（重組蛋白）

英文名稱： CASP5 Antigen (Recombinant Protein)

別     名：  caspase 5, apoptosis-related cysteine peptidase; ICH-3; ICEREL-III; ICE(rel)III

相關(guān)類別： 抗原

儲     存：  冷凍（-20℃）  

概     述

Fusion protein corresponding to a region derived from 235-434 amino acids of human CASP5

技術(shù)規(guī)格

Full name:

caspase 5, apoptosis-related cysteine peptidase

Synonyms:

ICH-3; ICEREL-III; ICE(rel)III

Swissprot:

P51878

Gene Accession:

BC113406

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.





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