英文名稱: CCM2 Antigen (Recombinant Protein)
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類別: 抗原
Full name: |
CCM2 scaffolding protein |
Synonyms: |
OSM; C7orf22; PP10187 |
Swissprot: |
Q9BSQ5 |
Gene Accession: |
BC004903 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. |