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  • 產(chǎn)品名稱:NEDD4L 抗原(重組蛋白)

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詳情介紹:



中文名稱: NEDD4L 抗原(重組蛋白)

英文名稱: NEDD4L Antigen (Recombinant Protein)

別     名:  neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; RSP5; NEDD4-2; NEDD4.2; hNEDD4-

儲(chǔ)   
  存:  冷凍(-20℃)

相關(guān)類別: 抗原

概      述

Fusion protein corresponding to C terminal 250 amino acids of human NEDD4L

技術(shù)規(guī)格

Full name:

neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Synonyms:

RSP5; NEDD4-2; NEDD4.2; hNEDD4-2

Swissprot:

Q96PU5

Gene Accession:

BC032597

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension.







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