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  • 產(chǎn)品名稱:PDZD3 抗原(重組蛋白)

  • 產(chǎn)品型號:100ug
  • 產(chǎn)品廠商:通蔚生物
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詳情介紹:


中文名稱: PDZD3 抗原(重組蛋白)

英文名稱: PDZD3 Antigen (Recombinant Protein)

別     名:  PDZ domain containing 3; IKEPP; PDZK2; NHERF4

儲     存:  冷凍(-20℃)

相關(guān)類別: 抗原

概     述

Fusion protein corresponding to a region derived from 372-571 amino acids of human PDZD3

技術(shù)規(guī)格

Full name:

PDZ domain containing 3

Synonyms:

IKEPP; PDZK2; NHERF4

Swissprot:

Q86UT5

Gene Accession:

BC029042

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).





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