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  • 產(chǎn)品名稱:兔抗RALBP1多克隆抗體

  • 產(chǎn)品型號(hào):100ul
  • 產(chǎn)品廠商:通蔚生物
  • 產(chǎn)品價(jià)格:1560
  • 產(chǎn)品庫(kù)存:60
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詳情介紹:
中文名稱:  兔抗RALBP1多克隆抗體  

英文名稱: Anti-RALBP1 rabbit polyclonal antibody

別      名: RALBP1; RIP1; RLIP1; RLIP76

相關(guān)類別: 一抗

儲(chǔ)      存: 冷凍(-20℃) 避光

宿      主: Rabbit

抗      原: RALBP1

反應(yīng)種屬: Human, Mouse, Rat

標(biāo) 記 物: Unconjugate

克隆類型: rabbit polyclonal

技術(shù)規(guī)格

Background:

The RalA binding protein 1 (RalBP1 or RLIP76) was originally identified as a GTP-RalA associated protein that acted as a downstream RalA effector in regulating Ral-Ras signaling). RalBP1 interacts with RalA and the endocytosis protein REPS2 (POB1) through its carboxy-terminal Ral binding domain. RalBP1 has an intrinsic GTPase activating function and interacts with Cdc42 through its centrally located Rho-GAP domain. A protein complex containing RalBP1/POB1/RalA regulates endocytosis of membrane receptors. RalBP1 also functions as a non-ABC transporter that catalyzes the ATP-dependent transport of numerous xenobiotics, including glutathione conjugates and some chemotherapeutic agents. RalBP1 transporter activity may play an important role in detoxification, drug resistance and the stress response). Increased expression of RalBP1 protein is associated with some forms of cancer and regression of cancer xenografts results from RalBP1 inhibition. Evidence to date suggests that RalBP1 may be a promising therapeutic target for cancer therapy.

Applications:

WB

Name of antibody:

RALBP1

Immunogen:

Fusion protein of human RALBP1

Full name:

ralA binding protein 1

Synonyms:

RALBP1; RIP1; RLIP1; RLIP76

SwissProt:

Q15311

WB Predicted band size:

76 kDa

WB Positive control:

K562 cells

WB Recommended dilution:

500-2000





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