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  • 產(chǎn)品名稱：DCAF1 抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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DCAF1 抗原（重組蛋白）深獲顧客信賴外，更帶給顧客喜悅和滿足，公司員工亦因此找到工作及生活的意義，將緊跟經(jīng)營管理和科學技術(shù)發(fā)展的步伐，提升和加強公司的市場競爭力，同心協(xié)力，盡展創(chuàng)意，致力于可持續(xù)發(fā)展、向社會盡責的企業(yè)宗旨。
詳情介紹：
中文名稱： DCAF1 抗原（重組蛋白）

英文名稱： DCAF1 Antigen (Recombinant Protein)

別     名：  DDB1 and CUL4 associated factor ; RIP; VPRBP

相關(guān)類別： 抗原

儲     存：  冷凍（-20℃）
  
概     述

Fusion protein corresponding to a region derived from 1308-1507 amino acids of human DCAF1

技術(shù)規(guī)格

Full name:

DDB1 and CUL4 associated factor

Synonyms:

RIP; VPRBP

Swissprot:

Q9Y4B6

Gene Accession:

BC022792

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714).






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