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  • 產(chǎn)品名稱(chēng)：KLHL12 抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：3580
  • 產(chǎn)品庫(kù)存：35
  • 產(chǎn)品文檔：
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中文名稱(chēng)： KLHL12 抗原（重組蛋白）

英文名稱(chēng)： KLHL12 Antigen (Recombinant Protein)

別     名：  kelch like family member 12; DKIR; C3IP1

儲(chǔ)     存：  冷凍（-20℃）  

相關(guān)類(lèi)別：抗原
 
概     述

Fusion protein corresponding to a region derived from 369-568 amino acids of human KLHL12

技術(shù)規(guī)格

Full name:

kelch like family member 12

Synonyms:

DKIR; C3IP1

Swissprot:

Q53G59

Gene Accession:

BC003183

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants.







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