中文名稱: MVK 抗原(重組蛋白)
英文名稱: MVK Antigen (Recombinant Protein)
別 名: mevalonate kinase; MK; LRBP; MVLK; POROK3
相關(guān)類別: 抗原
概 述
Full name: |
mevalonate kinase |
Synonyms: |
MK; LRBP; MVLK; POROK3 |
Swissprot: |
Q03426 |
Gene Accession: |
BC016140 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. |